Outcome predictors of Gamma Knife radiosurgery for renal cell carcinoma metastases - Abstract

Although whole brain radiation therapy (WBRT) has been a standard palliative management for brain metastases from renal cell carcinoma, its benefit has been elusive because of radiobiological resistance.

We evaluated the role of stereotactic radiosurgery (SRS) in the management of brain metastases from renal cell carcinoma.

We reviewed records from 158 consecutive patients (male=111, female=47) who underwent SRS for 531 brain metastases from renal cell carcinoma. The median patient age was 61 years (38-83 years) and the median number of tumors per patient was one (1-10). Seventy-nine patients (50%) had solitary brain metastasis. Fifty-seven patients (36%) underwent prior WBRT. The median total tumor volume for each patient was 3.0 cc (0.09-47 cc).

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