Gamma Knife Radiosurgery for Symptomatic Brainstem Intra-axial Cavernous Malformations

The purpose of this study was to evaluate the efficacy and safety of gamma knife radiosurgery (GKRS) for the treatment of symptomatic brainstem intraaxial cavernous malformations (CMs) associated with high surgical morbidity. Twenty-one patients with symptomatic brainstem intra-axial CMs were treated by GKRS between 2005 and 2010. One patient was lost to follow up. The median age of the patients was 39.5 years (range 24−69 years). All patients had experienced 1 or more symptomatic hemorrhages before GKRS (range 1−3). The median marginal radiation dose was 13 Gy, and the median volume of the malformation was 0.56 mL. The median follow-up period after radiosurgery was 32 months (range 12−82 months, mean 38.9 months). Before GKRS, 31 hemorrhages (1.55 per patient) were observed.

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