In the past, some brain tumors and central nervous system disorders were considered inoperable if they were located deep within the brain or near delicate structures such as the auditory nerve.  Now, with the revolutionary development and introduction of Gamma Knife® stereotactic radiosurgery, these conditions can be effectively reduced and even eliminated without any sutures or scalpels.
What is Gamma Knife®?
Gamma Knife® Perfexion is an advanced medical technology that was designed specifically for use on abnormalities in the brain and cervical spine.  Using 192 intersecting beams of precisely aimed radiation, the Gamma Knife® can target even the most deeply seated or hard-to-reach tumors, arteriovenous malformations, or neurological conditions.  Due to the machine’s unparalleled accuracy compared with other radiation treatments, the abnormalities can be thoroughly irradiated while healthy tissue is spared.  This amazing ability helps to keep any side effects from treatment to a minimum.
How does Gamma Knife® work?
Although the treatment is known as stereotactic radiosurgery, no scalpels are involved in treatment.  Once the tumor or other tissue abnormality is evaluated with MRI or CT scanning, a specialized head frame is placed to ensure precise delivery of radiation to the affected site.  The Gamma Knife® then emits focused beams of cobalt-60 radiation on the abnormal tissue within a 0.15 mm accuracy range.  The dosage and other parameters are carefully adjusted by the Gamma Knife® treatment team to ensure optimal safety and results from the treatment.  In many cases, the radiation can diminish or even eliminate the cancerous or abnormal tissue.
At the Miami Neuroscience Center, our experienced team of multidisciplinary professionals offers the highest quality in Gamma Knife® treatment in a comfortable atmosphere.  If you are interested in learning more about how this technology may be able to benefit you or your loved one, call our helpful staff today at (786) 347-1505—we are happy to answer your questions.

Gamma knife radiosurgery for intracranial cavernous malformations

To analyze and evaluate the role of Gamma knife radiosurgery (GKRS) and clinical outcome in patients with intracranial cavernous malformations. The medical records of 96 patients who underwent radiosurgery at our institute were reviewed retrospectively.After a mean follow-up period of 4.3 years, 

Gamma Knife Radiosurgery for Symptomatic Brainstem Intra-axial Cavernous Malformations

The purpose of this study was to evaluate the efficacy and safety of gamma knife radiosurgery (GKRS) for the treatment of symptomatic brainstem intraaxial cavernous malformations (CMs) associated with high surgical morbidity. Twenty-one patients with symptomatic brainstem intra-axial CMs were treated by GKRS between 2005 and 2010. One patient was lost to follow up. The median age of the patients was 39.5 years (range 24−69 years). All patients had experienced 1 or more symptomatic hemorrhages before GKRS (range 1−3). The median marginal radiation dose was 13 Gy, and the median volume of the malformation was 0.56 mL. The median follow-up period after radiosurgery was 32 months (range 12−82 months, mean 38.9 months). Before GKRS, 31 hemorrhages (1.55 per patient) were observed.

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Group Florence Nightingale Increases Radiosurgery Profile with Acquisition of Turkey's First Leksell Gamma Knife Perfexion System

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Patients from Turkey and abroad receive minimally invasive radiosurgery for cancer and other brain disorders on Elekta's most advanced radiosurgery system
ISTANBUL, Sept. 19, 2012 /PRNewswire/ -- Leksell Gamma Knife® Perfexion™ – Elekta's most advanced Gamma Knife® platform – became Turkey's fifth Gamma Knife system, beginning clinical operation at Group Florence Nightingale's Comprehensive Cancer Center (Istanbul) on May 25. The Cancer Center's Prof. Dr. Talat Kiris used Perfexion for the first time by treating a 15-year-old Iraqi boy with a partially resected skull base tumor.
Gamma Knife radiosurgery is a patient friendly alternative to traditional brain surgery for illnesses such as metastatic disease, arteriovenous malformations (AVM) and meningiomas. With pinpoint accuracy, the system delivers up to thousands of low-intensity radiation beams to one or more targets in a single session. Perfexion provides even greater speed and ease of use than previous models.
According to Prof. Dr. Kiris, both he and the Group's administration were strongly committed to acquiring Perfexion for the Comprehensive Cancer Center due to the proven effectiveness of Gamma Knife surgery and to the added sophistication of the Perfexion system.
"For years, Gamma Knife surgery has the accepted gold standard for the treatment of many intracranial indications," Prof. Dr. Kiris observes. "In addition, compared to previous Gamma Knife models, Perfexion dramatically streamlines the radiosurgery workflow and expands the treatable volume with a new collimator. Treatment delivery to one or more tumors in a single session also is greatly facilitated in Perfexion, and allows treatment of a wider range of targets faster, more efficiently and safer than before.
"For me, Perfexion is a neurosurgeon's tool," he continues. "It's very easy to use and if you know brain anatomy very well, the system software helps you a lot."
First clinical cases successful
The first Perfexion case involving the boy from Iraq was unusual, he says.
"It was a highly vascular lesion that bled significantly during resection, so we stopped the surgery, leaving part of it intact. He had radiosurgery with Perfexion and everything went perfectly. He flew back to his country the next morning."
The second Perfexion patient came the very same day, a Bulgarian man with a vestibular schwannoma, a common Gamma Knife radiosurgery indication. This patient also left the hospital on the day of his surgery. Since then, eight other private patients – encompassing an AVM and a metastasis, meningiomas and trigeminal neuralgia – have undergone Perfexion radiosurgery.
"On July 5, we treated a patient with a brain stem tumor from Azerbaijan and the following week we treated two more patients, one with an AVM and one with a vestibular schwannoma," he notes. "Next year, I predict we will treat increasing numbers of patients with one or more metastases."
For further information, please contact:Johan Andersson Melbi, Investor Relations Manager, Elekta AB
Tel: +46 702 100 451, email:  Time zone: CET: Central European Time
Michelle Joiner, Director, Global Public Relations and Brand Management, Elekta
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About Elekta
Elekta is a human care company pioneering significant innovations and clinical solutions for treating cancer and brain disorders. The company develops sophisticated, state-of-the-art tools and treatment planning systems for radiation therapy, radiosurgery and brachytherapy, as well as workflow enhancing software systems across the spectrum of cancer care. Stretching the boundaries of science and technology, providing intelligent and resource-efficient solutions that offer confidence to both healthcare providers and patients, Elekta aims to improve, prolong and even save patient lives.
Today, Elekta solutions in oncology an

Long-term Results of Gamma Knife Surgery for Partially Embolized Arteriovenous Malformations.


1Lars Leksell Center for Gamma Surgery, Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia, USA 2Department of Radiology, University of Virginia, Charlottesville, Virginia, USA.



The effectiveness and risk of Gamma Knife surgery (GKS) in the management of partially embolized cerebral arteriovenous malformations (AVMs) remain to be elucidated.


To evaluate the long-term imaging and clinical outcomes of GKS in AVM patients who had undergone prior partial embolization and compare the results with patients treated with GKS alone.


A total of 215 embolized AVMs were analyzed. The mean age was 32.9 years. The mean volume of the nidus was 4.6 cc (range 0.1-29.4 cc) and the mean prescription dose was 19.6 Gy (range 4-28 Gy). This group was compared with 729 non-embolized AVMs.


Following embolization and GKS, angiographically confirmed total obliteration of the AVMs was significantly lower (33%) when compared with patients where GKS was used alone (60.9%; p< 0.001). However, the mean nidus size was larger and the Spetzler Martin grade was higher for the embolized AVMs compared to the non-embolized AVMs. Radiation-induced changes occurred more often in the embolized (43.4%) than the non-embolized (33.4%) AVMs (p=0.028). Permanent neurological deficits associated with radiation-induced changes occurred in 2.7% of the embolized versus 1.3% of the non-embolized patients (p=0.14).


In our retrospective and historical series, the long-term results suggest that the obliteration rate is significantly lower in embolized AVMs versus non-embolized AVMs also due to the fact that the combined treatment is applied to higher grade AVMs; the percentage of grade III - V AVMs was 58.6% and 48.8% for non-embolized AVMs.
[PubMed - as supplied by publisher]


Gamma Knife surgery is the gold standard for the treatment of intracranial pathology. Its clinical efficacy has been documented across nearly four decades, with more than 500,000 cases treated worldwide providing the data for 2,500+ publications in peer-reviewed medical literature. It is used as the performance standard against which other technologies (such as CyberKnife) are measured.

Perhaps the easiest way to state our case is to compare, point for point, the Gamma Knife with the CyberKnife.

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