On demand Gamma-knife strategy can be safely combined with BRAF-inhibitors for the treatment of melanoma brain metastases

Annals of Oncology,   Clinical Article

Gaudy–Marqueste C, et al. – Both Gamma–Knife radiosurgery (GKRS) and BRAF–inhibitors (BRAF–I) have been shown to be useful in melanoma patients with brain metastases (BM), thus suggesting that it could be interesting to combine their respective advantages. Interrupting BRAF–I for stereotactic radiosurgery of BM seems useless, although it is still advised for other radiation therapies. The potential benefit of combining stereotactic radiosurgery and BRAF–I can be safely tested.

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